HUMAN-DERIVED BIOMATERIALS

Natural bone matrix as a local therapeutic depot

Allogeneic bone tissue combines a biological scaffold for osseointegration with the controlled local release of an antibacterial agent.

TM OSTEOMET / ALLOGENEIC BONE

Human-derived, not synthetic or animal-derived material

The bioimplant is based on allogeneic bone tissue. Its natural architecture serves as a matrix for replacing bone defects and as a carrier for a medicinal substance at the implantation site.

TM OSTEOMET range of human-derived biomaterials

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TM OSTEOMET PRODUCT RANGE

Cancellous bone fraction 4–10 mm, volume 10 cm³

OSTEOMET

Pure cancellous bone fraction

Without antibiotic

OSTEOMET V

Impregnated with vancomycin

Gram-positive flora

OSTEOMET G

Impregnated with gentamicin

Gram-negative flora

OSTEOMET R

Impregnated with rifampicin

Biofilms

OSTEOMET T

Impregnated with tobramycin

Gram-negative flora

BIOIMPLANT FOR DENTISTRY AND MAXILLOFACIAL SURGERY

Combined cortical-cancellous structure

The concept combines components with different densities and release rates to form a multiphase local depot.

Cancellous fraction

0.25–1.5 mm

Rapid loading and the initial release phase.

Demineralised cortical matrix

0.15–0.85 mm

Mechanical stabilisation and a prolonged release phase.

Antibacterial agent

Local depot

The medicine or combination is selected by the physician.

CONTROLLED RELEASE

Multiphase profile at the implantation site

0–24 h

Initial phase

Rapid achievement of a local bactericidal concentration.

1–7 days

Stabilisation

Maintenance of the therapeutic concentration of the antibacterial agent.

7–21 days

Prolonged phase

Controlled concentration reduction and sustained local action.

IMPREGNATION OPTIONS

Broad-spectrum antibacterial agents

Antibiotic	Class	Spectrum	Feature
Gentamicin	Aminoglycosides	Gram-negative flora	Base option
Vancomycin	Glycopeptides	Gram-positive flora	Including MRSA
Rifampicin	Ansamycins	Biofilms	Synergistic action
Tobramycin	Aminoglycosides	Gram-negative flora	Local action
Clindamycin	Lincosamides	Anaerobic flora	For dentistry
Azithromycin	Macrolides	Broad spectrum	Anti-inflammatory action
Meropenem	Carbapenems	Broad spectrum	MDR pathogens

CLINICAL APPLICATIONS

Dentistry and maxillofacial surgery

Alveolar ridge preservation

Post-extraction socket filling

Sinus lift

Preparation for dental implantation

Bone defect replacement

Comprehensive treatment of jaw osteomyelitis

This information is intended for medical professionals. The specific indications, material form and antibacterial agent are determined by the physician according to the clinical situation.